鄭鴻翔

教師基本信息

姓名：鄭鴻翔

職稱：青年副研究員

電子郵箱：zhenghongxiang@fudan.edu.cn

辦公地點：生命科學學院B605

研究方向

生物信息學；計算生物學；群體遺傳學；分子進化。

主要通過生物信息學方法，圍繞線粒體基因組(mitochondrial DNA)進行人類進化遺傳學和群體遺傳學研究，涉及以下幾個方麵：1）人群的擴張、遷徙和所受到自然選擇作用等進化曆史；2）線粒體DNA變異在人類表型和疾病中的作用；3）跨物種線粒體DNA分子進化研究；4）核基因組中線粒體DNA插入序列研究。

個人簡介

2006年於複旦大學生命科學學院獲得生物技術學士學位，2012年於複旦大學獲得遺傳學博士學位。2012-2018於複旦大學從事科研助理和博士後研究。2018年起於複旦大學生命科學學院任職青年副研究員。

主持國家自然科學基金委青年科學基金項目和麵上項目。

招生專業

長期招收生物信息學和進化遺傳學專業研究生。

代表性論文和論著

1. Tao Y†, Wei Y†, Ge J†, Pan Y†, Wang W, Bi Q, Sheng P, Fu C, Pan W, Jin L, Zheng HX# , Zhang M#. Phylogenetic evidence reveals early Kra-Dai divergence and dispersal in the late Holocene. Nature Communications. 2023 Oct 30;14(1):6924.

2. Ning C†, Zheng HX† , Zhang F†, Wu S, Li C, Zhao Y, Xu Y, Wei D, Wu Y, Gao S*, Jin L*, Cui Y*. Ancient Mitochondrial Genomes Reveal Extensive Genetic Influence of the Steppe Pastoralists in Western Xinjiang. Frontiers in Genetics. 2021 ,12:740167.

3. Sun D†, Niu Z†, Zheng HX†, Wu F, Jiang L, Han TQ, Wei Y, Wang J*, Jin L*. A mitochondrial DNA variant elevates the risk of gallstone disease by altering mitochondrial function. Cellular and Molecular Gastroenterology and Hepatology, 2021;11(4):1211-1226.e15.

4. Zhang M†, Zheng HX†, Yan S*, Jin L*. Reconciling the father tongue and mother tongue hypotheses in Indo-European populations. National Science Review, 2019, 6(2):293-300.

5. He L†, Zheng HX†, Wang Y, Le KY, Liu Q, Shang J, Dai Y, Meng H, Wang X, Li T, Gao Q, Qin J, Lu H, Otto M*, Li M*. Detection and analysis of methicillin-resistant human-adapted sequence type 398 allows insight into community-associated methicillin-resistant Staphylococcus aureus evolution. Genome Medicine, 2018, 10(1):5.

6. Zheng HX†, Li L†, Jiang XY†, Yan S, Qin Z, Wang X*, Jin L*. MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population. Human Genetics, 2017,136(10):1353-1362.

7. Kang L†*, Zheng HX†, Zhang M, Yan S, Li L, Liu L, Liu K, Hu K, Chen F, Ma L, Qin Z, Wang Y, Wang X, Jin L*. MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders. Scientific Reports, 2016, 6:31083.

8. Yin M†, Zheng HX†, Su J, Feng Z, McManus DP, Zhou XN, Jin L, Hu W*. Co-dispersal of the blood fluke Schistosoma japonicum andHomo sapiens in the Neolithic Age. Scientific Reports, 2015, 5:18058.

9. Kang L†*, Zheng HX†, Chen F, Yan S, Liu K, Qin Z, Liu L, Zhao Z, Li L, Wang X, He Y, Jin L*. mtDNA lineage expansions in Sherpa population suggest adaptive evolution in Tibetan highlands. Molecular Biology and Evolution, 2013, 30(12):2579-87.

10. Zheng HX, Yan S, Qin ZD, Jin L*. MtDNA analysis of global populations support that major population expansions began before Neolithic Time. Scientific Reports, 2012, 2:745.

11. Zheng HX†, Yan S†, Qin ZD, Wang Y, Tan JZ, Li H, Jin L*. Major population expansion of East Asians began before Neolithic Time: Evidence of mtDNA genomes. PLoS One, 2011, 6(10):e25835.