基本信息
職稱：教授
郵箱：microbiome@fudan.edu.cn;gpzhao@sibs.ac.cn ;
地址：複旦大學生命科學學院A103室
個人簡介
分子微生物學家，中國科學院院士，發展中國家科學院院士，美國微生物科學院院士。現任複旦大學生命科學學院微生物學和免疫學係主任，中科院上海營養與健康研究所生物醫學大數據中心首席科學家，中科院深圳先進技術研究院合成生物學研究所首席科學家，中科院分子植物科學卓越創新中心合成生物學重點實驗室專家委員會主任，山東大學公共衛生學院健康醫療大數據研究院/國家健康醫療大數據研究院首席科學家；兼任中國生物工程學會合成生物學專業委員會主任，上海生物工程學會名譽理事長。
主要研究方向
研究領域涉及微生物基因組學、係統與合成生物學以及生物信息學等方麵。曾參與啟動中國人類基因組計劃及相關生命“組學”研究，克隆若幹遺傳病致病基因；主持若幹重要微生物的基因組、功能基因組、比較和進化基因組研究，解析SARS冠狀病毒分子進化機製。在細菌蛋白質乙酰化組和腸道微生物組等領域作出若幹開創性工作。組建並領導中科院合成生物學重點實驗室，在酵母染色體重構，代謝組與代謝流量組研究，天然化合物細胞工廠製造，基因編輯技術研發等方向上，實現重要突破。近年來，參與組建並領導中國科學院上海生命科學研究院（現營養與健康研究所）生物醫學大數據中心，為建設國家生物醫學大數據綜合性服務平台開展預研工作。
代表性文章
1. W. Dong et al., Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence. Proc Natl Acad Sci U S A 118,(2021).
2. W. Tan et al., A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation. J Biol Chem 295, 5051-5066 (2020).
3. P. Li, H. Zhang, G. P. Zhao, W. Zhao, Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor. Nucleic Acids Res 48, 4902-4914 (2020).
4. T. Liao, Y. Wei, M. Luo, G. P. Zhao, H. Zhou, tmap: an integrative framework based on topological data analysis for population-scale microbiome stratification and association studies. Genome Biol 20, 293 (2019).
5. S. Y. Li et al., CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA. Cell Res 28, 491-493 (2018).
6. S. Y. Li et al., CRISPR-Cas12a-assisted nucleic acid detection. Cell Discov 4, 20 (2018).
7. C. Lei et al., The CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitro. Nucleic Acids Res 45, e74 (2017).
8. G. Liu et al., Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci Rep 3, 1569 (2013).
9. B. Zhang et al., An efficient procedure for marker-free mutagenesis of S. coelicolor by site-specific recombination for secondary metabolite overproduction. PLoS One 8, e55906 (2013).
10. S. Hu et al., Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018. BMC Genomics 12, 93 (2011).
11. P. Hao et al., Complete sequencing and pan-genomic analysis of Lactobacillus delbrueckii subsp. bulgaricus reveal its genetic basis for industrial yogurt production. PLoS One 6, e15964 (2011).
12. Y. X. Wei et al., Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol 192, 4076-4077 (2010).
13. C. Zhang et al., Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 4, 232-241 (2010).
14. Q. Wang et al., Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327, 1004-1007 (2010).
15. X. Ou, B. Zhang, L. Zhang, G. Zhao, X. Ding, Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Appl Environ Microbiol 75, 2158-2165 (2009).
16. Z. Y. Zhang et al., Complete genome sequence of Lactobacillus plantarum JDM1. J Bacteriol 191, 5020-5021 (2009).
17. M. Li et al., Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 105, 2117-2122 (2008).
18. S. X. Ren et al., Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422, 888-893 (2003).