教師基本信息
職稱：副教授
辦公地點：複旦大學生命科學學院D503室
辦公電話：021-31246571
個人簡介
女，博士，副教授，博士研究生導師。1992年獲得武漢大學理學學士學位，2003年獲得福建師範大學理學碩士學位，2006年獲天津科技大學工學博士學位。2006-2008年進入複旦大學生命科學博士後流動站從事研究。2009年至今，複旦大學生命科學學院工作。2013-2014年，多倫多大學醫學院，訪問學者。主要從事病原微生物分子遺傳學的相關研究。
研究方向
應用分子生物學與遺傳學、微生物學、生物信息學、免疫學等技術手段，研究結核病相關的細菌毒力機製及其基因調控網絡；研究結核潛伏感染過程中病原-宿主互作機製；構建驗證新型抗結核BCG疫苗、亞單位疫苗並探索免疫機製。在此基礎上發掘結核病分子診斷標識或藥物靶標、新型抗結核疫苗。
獲獎情況
全國大學生生命科學創新創業大賽，指導教師一等獎。2017年。
代表性論文和論著
1. Jun Jiang#, Chen Lin #,,, Yao Li*, Lu Zhang*, Jun Liu*. 2020. Transcriptome changes of Mycobacterium marinum in the process of resuscitation from hypoxia-induced dormancy. Frontiers in Genetics. 10: 1359.
2. Ding-qianLiu#,,, Lu Zhang*,Qing-zhongWang*. 2020. Over-expression of Tgs1 in Mycobacterium marinum enhances virulence in adult zebrafish. International Journal of Medical Microbiology. 310: 151378.
3. Juntao Mai#,,, Lu Zhang* and Jun Liu*. 2019. Mycobacterium tuberculosis 6C sRNA binds multiple mRNA targets via C-rich loops independent of RNA chaperones. Nucleic Acids Research. 47(8): 4292–4307.
4. Xian Sun#, Lu Zhang#,,, Jun Liu*. 2018. Transcription factors Rv0081 andRv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis.Virulence. 9(1): 1468–1482.
5. Jing Wu#,,, Lu Zhang* and Jun Liu*. 2017. WhiB4 Regulates the PE/PPE Gene Family and is Essential for Virulence of Mycobacterium marinum.Scientific Reports. 7(1): 3007.
6. Huanwei Ru#,,, Lu Zhang* and Jun Liu*. 2017. The impact of genome region of difference 4 (RD4) on mycobacterial virulence and BCG efficacy. Frontiers in Cellular andInfection Microbiology. 7:239.
7. Zhi-hao Xiang#,,, Lu Zhang* and Jun Liu*. 2017. Immunogenicity and protective efficacy of a fusion protein tuberculosis vaccine combining five Esx family proteins. Frontiers in Cellular and Infection Microbiology. 7:226.
8. Liu Dan#,,, Zhang Lu* and Wang Qingzhong*. 2017. Rv2629 Overexpression Delays Mycobacterium smegmatis andMycobacteria tuberculosis Entry into Log-Phase and Increases Pathogenicity of Mycobacterium smegmatis in Mice. Frontiers in Microbiology. 8:2231.
9.Lu Zhang#,,, Jun Liu*. 2016. Variable virulence and efficacy of BCG vaccine strains and correlation with genome polymorphisms. Molecular Therapy. 24(2): 398-405.
10. Wen-xi Xu, Lu Zhang*,,, Honghai Wang*. 2014. The Wag31 protein interacts with AccA3 and coordinates cell wall lipid permeability and lipophilic drug resistance in Mycobacterium smegmatis.Biochemical and Biophysical Research Communications. 448: 255–260.
11. Peng Chao, Zhang Lu*,,, Honghai Wang*. 2012. Mtb9.9 protein family: an immunodominant antigen family of Mycobacterium tuberculosis induces humoral and cellular immune responses in mice. Human Vaccines Immunotherapeutics. 8(4): 435-442.
12.Lu Zhang*,,, Honghai Wang*. 2012. Identification of putative biomarkers for the serodiagnosis of drug-resistant Mycobacterium tuberculosis.Proteome Science. DOI: 10.1186/1477-5956-10-12.