姓名：公曉紅
職稱：副教授
電子郵箱：gongxh@fudan.edu.cn
辦公地點：江灣校區生科樓A605
辦公電話：021-31246609
研究方向
精神分裂症、雙相障礙、重性抑鬱症、孤獨症等重性精神疾病嚴重危害人類健康。課題組從基因組學、代謝組學、蛋白組學、腦影像等多層次研究精神疾病的基因型-表型關係，挖掘生物標誌物以促進疾病的客觀診斷；采用小鼠模型解析人類精神疾病重要基因變異的分子病理機製。
個人簡介
北京大學醫學學士、博士。2005-2007年在法國Institute Pasteur進行博士後研究。2007年起在複旦大學任教。
授課情況：《精神衛生學概論》、《人類進化》、《遺傳與疾病》
招生專業：遺傳學
代表性論文和論著：
Hao M#, Qin Y#, Li Y#, Tang Y, Ma Z, Tan J, Jin L, Wang F*,Gong X*.Metabolome subtyping reveals multi-omics characteristics and biological heterogeneity in major psychiatric disorders. Psychiatry Res. 2023 Nov 13;330:115605.
Qin Y#, Zhang XY#, Liu Y#, Ma Z, Tao S, Li Y, Peng R, Wang F, Wang J, Feng J, Qiu Z, Jin L, Wang H*,Gong X*.Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice. Transl Psychiatry. 2023 Oct 25;13(1):329.
Yue Qin# , Yasong Du# , Liqiang Chen , Yanyan Liu , Wenjing Xu , Ying Liu , Ying Li , Jing Leng , Yalan Wang , Xiao-Yong Zhang , Jianfeng Feng , Feng Zhang , Li Jin , Zilong Qiu , Xiaohong Gong* , Hongyan Wang* . A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling. Molecular Psychiatry. 2022 Jul;27(7):2985-2998.
Kang J, Jiao Z, Qin Y, Wang Y, Wang J, Jin L, Feng J, Wang F, Tang Y*, Gong X*.Associations between polygenic risk scores and amplitude of low-frequency fluctuation of inferior frontal gyrus in schizophrenia.J Psychiatr Res. 2022 Jan 3;147:4-12. doi: 10.1016
Zhu Y#, Wang S#, Gong X#, Edmiston EK, Zhong S, Li C, Zhao P, Wei S, Jiang X, Qin Y, Kang J, Wang Y, Sun Q, Gong G, Wang F, Tang Y.Associations between hemispheric asymmetry and schizophrenia-related risk genes in people with schizophrenia and people at a genetic high risk of schizophrenia.Br J Psychiatry. 2021 Jul;219(1):392-400.
Chang M#, Womer FY#,Gong X#, Chen X, Tang L, Feng R, Dong S, Duan J, Chen Y, Zhang R, Wang Y, Ren S, Wang Y, Kang J, Yin Z, Wei Y, Wei S, Jiang X, Xu K, Cao B, Zhang Y, Zhang W, Tang Y*, Zhang X*, Wang F*. Identifying and validating subtypes within major psychiatric disorders based on frontal-posterior functional imbalance via deep learning. Mol Psychiatry. 2021 Jul;26(7):2991-3002.
Qin Y#, Kang J#, Jiao Z, Wang Y, Wang J, Wang H, Feng J, Jin L, Wang F, Gong X. Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia. Transl Psychiatry. 2020 Sep 21;10(1):322.
Zhang L#,Qin Y#,Gong X#,Peng R,Cai C,Zheng Y,Du Y, and Wang H. A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population. Transl Psychiatry. 2019 Jan 22;9(1):31.