教師基本信息：
姓名：王久存
職稱：教授
職務：人類遺傳學與人類學係係主任
電子郵箱：jcwang@fudan.edu.cn
辦公地點：生科樓六樓
研究方向：
硬皮病、強直性脊柱炎等風濕免疫性疾病的遺傳學及分子致病機理研究、皮膚表型組學研究及人類高原習服表型組學研究。
建立了多中心研究隊列；發現成纖維細胞生長因子6（FGF6）是新的鐵代謝調控基因（Blood 2019）；發現低密度脂蛋白受體LDLR缺失可誘發LDL累積並促進肺纖維化發生，LDLR在保護肺組織免受損傷及抗纖維化中發揮重要作用（；發現中國人群存在兩種微生物皮膚型，初步解析了中國漢族人群皮膚微生物組特征（Microbiome 2021）；發現高海拔暴露各階段多器官係統間的縱向協同反應變化規律和個體生理異質性（。
個人簡介：
1988及1991年分獲複旦大學生物係學士及碩士學位，1999年獲日本福井大學生物應用化學專業博士學位。2007-2008年於美國德克薩斯大學休斯頓健康科學中心訪問研究。1991-1994年任複旦大學生命科學學院助教、講師。2000起任複旦大學生命科學學院講師、副教授、教授。
現任生命科學學院人類遺傳學與人類學係係主任，附屬華山醫院雙聘教授，皮膚表型組學研究聯合實驗室共同主任，複旦大學風濕免疫過敏性疾病研究中心副主任；中國醫學科學院皮膚及皮膚病群體遺傳學和防控新技術研究創新單元共同主任；上海人類學學會會長，中國遺傳學會理事；聯合發起硬皮病臨床與研究國際協作網（InSCAR）並任副理事長。任Laboratory Investigation、Journal of Scleroderma and Related Disorders等雜誌編委。
正在承擔國家重點研發計劃“發育編程及其代謝調節”重點專項項目（首席科學家）、國家自然科學基金重點項目及區域創新發展聯合基金重點項目、上海市市級重大專項子項目、中國醫學科學院創新基金等項目。曾作為Site-PI（地區PI）承擔NIH-U01項目，主持中國地區硬皮病及強直性脊柱炎HLA區域精細結構分析。發表論文200餘篇，近五年來以通訊作者在包括National Science Review、Blood、Annals of The Rheumatic Diseases、Microbiome等在內的高影響力雜誌發表論文五十餘篇。獲教育部科技進步獎一等獎（2022年度，第二完成人）及首屆複旦大學劉祖洞人類遺傳學獎教金一等獎（2023）等獎勵。
授課情況：
生物科學導論、人類表型組學、疾病中的生命科學
招生專業：遺傳學、生物信息學、人類生物學
科研項目：
國家重點研發計劃“發育編程及其代謝調節”重點專項項目（首席）
國家自然科學基金重點項目
國家自然科學基金區域創新發展聯合基金重點項目
上海市市級重大專項子項目
中國醫學科學院創新基金
獲獎情況：
首屆複旦大學劉祖洞人類遺傳學獎教金一等獎（2023）
教育部科技進步獎一等獎（2022年度，第二完成人）
2021年度上海市教育係統巾幗文明崗
2019-2020年度複旦大學三八紅旗集體
遺傳與發育協同創新中心2019年度“十大科技進展”
複旦大學風濕免疫過敏性疾病研究中心首屆年度“精英獎”（2012）
代表性論文和論著：
1) Huang Y#, Zhao H#, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y*,*, Liu Q*. Enhancement of zyxin promotes skin fibrosis by regulating FAK/PI3K/AKT and TGF-β signaling pathways via integrins. . 2023 Apr 29;19(8):2394-2408.
2) Ma Y#, Tan Yimei, Hu Y, Pu W, Xu J, Jin L*, *. Quantitative assessment of ultraviolet-induced erythema and tanning responses in the Han Chinese population, , 2023.
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4) Liu J#, Huang Y#, Gong Y#, Liu Q#, Lin J#, Liu J#, Liu M, Huang J, Pu W, Ma Y, Zhang Y, Li H, Shi X, Zhang Y, Wang J, Zhu Y, Wang Q, Wei K, Wang J, Sha Y, *, Wu W*. CTHRC1+ fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids. . 2022 Dec;12(12):e1115.
5) Shi X, Chen Y, Liu Q, Mei X, Liu J, …, Zou H, Zhao S, Distler JHW, Jin L, Wang J*. LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clinical and Translational Medicine. 2022 Jan;12(1):e711. doi: 10.1002/ctm2.711. PMID: 35083881.
6) Pu W#, Zhang R#, Ma Y, Liu Q, Jiang S, Liu J, Zhao Y, Tu W, Guo G, Zuo X, Wang Q, Chen Y, Wu W, Zhou X, Distler JHW, Reveille JD, Zou H, Jin L, Mayes MD, Wang J*. Genetic associations of non-major histocompatibility complex susceptibility loci with systemic sclerosis in a Han Chinese population. Journal of Investigative Dermatology2022Jul;142(7):2039-2042.e7.
7) Pu W#, Wu W#, Liu Q#, Ma Y#, Tu W#, Zuo X#, Guo G#, Jiang S, Zhao Y, Zuo X, Wang Q, Yang L, Xiao R, …, Qi Q, Bai P, Zhao L, Reveille JD, Mayes MD, Jin L, Lee EB, Zhang X, Xu J*, Zhang Z*, Zhou X*, Zou H*, Wang J*. Exome-wide association analysis suggests LRP2BP as a susceptibility gene for endothelial injury in systemic sclerosis in Han Chinese population. Journal of Investigative Dermatology. 2021 May;141(5):1254-1263.e6.
8) Liu J#, Tang Y#, Huang Y#, Gao J, Jiang S, Liu Q, Ma Y, Qian X, Qian F, Reveille JD, He D, Zou H, Jin L, Zhu Q*, Pu W*, Wang J*. Single-cell RNA sequencing deciphers innate immunity in pathogenesis and treatment response of ankylosing spondylitis. Clinical and Translational Medicine. 2021 Mar;11(3):e369.
9) Li Z#, Xia J#, Jiang L#, Tan Y#, An Y, Zhu X, Ruan J, Chen Z, Zhen H, Ma Y, Jie Z, Xiao L, Yang H, Wang J, Kristiansen K, Xu X, Jin L, Nie C*, Krutmann J*, Liu X*, Wang J*. Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome. 2021 Feb 17;9(1):47. (Video Byte: https://www.researchsquare.com/article/rs-276355/v1)
10) Sun D#, Niu Z#, Zheng H#, Wu F, Jiang L, Han TQ, Wei Y, Wang J*, Jin L*. A mitochondrial DNA variant elevates the risk of gallstone disease by altering mitochondrial function. Cellular and Molecular Gastroenterology and Hepatology. 2020 Dec 4:S2352-345X(20)30199-5.
11) Liu J#, Pu W#, Li Y, Ma Y, Zhu Q, Wan W, Yang C, Wang X, Chen X, Zhou X, Reveille JD, Jin L, Zou H*, Wang J*. Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population. Annals of the Rheumatic Diseases. 2019 Jun;78(6):852-853.
12) Guo S#, Jiang S#, Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang M, Kitchner T, Joyce J, An P, Wang F, Strenn R, Mazza JJ, Meece JK, Wu W, Jin L, Smith JA, Wang J* and Schrodi SJ*. A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene. Blood. 2019Apr 25;133(17):1888-1898.
13) Ding W#, Pu W#, Jiang S, Ma Y, Liu Q, Wu W, Chu H, Zou H, Jin L, Wang J*, Zhou X*. Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3. EBioMedicine. 2018 Dec;38:238-247.
14) Ding W#, Pu W#, Wang L#, Jiang S, Zhou X, Tu W, Yu L, Zhang J, Guo S, Liu Q, Ma Y, Chen S, Wu W, Reveille J, Zou H, Jin L, Wang J*. Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of interferon-associated genes in CD4+ and CD8+ T cells. Journal of Investigative Dermatology. 2018 May;138(5):1069-1077.
15) Chu H#, Jiang S#, Liu Q, Ma Y, Zhu X, Liang M, Shi X, Ding W, Zhou X, Zou H, Qian F, Shaul PW, Jin L*, Wang J*. Sirtuin1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes. American Journal of Respiratory Cell and Molecular Biology. 2018 Jan;58(1):28-39.
16) Dong Z#, Li Y#, Zhou J, Jiang S, Wang Y, Chen Y, Zhao D, Yang C, Qian Q, Ma Y, He H, Ji H, Yang Y, Wang X, Xu X, Pang Y, Zou H, Jin L, Zhang F*, Wang J*. Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout. Protein & Cell. 2017 Jun;8(6):467-470.
Dr. Jiucun Wang is a professor at the School of Life Sciences and Human Phenome Institute, and adjunct Professor of Huashan Hospital, Fudan University, Shanghai, China. She works on the genetics and molecular mechanism of systemic sclerosis, as well as the skin phenome including skin microbiome. As a Site PI, she led the Chinese effort in one NIH-U01 project entitled “Studies of HLA Region Genomics in Systemic Sclerosis and Ankylosing Spondylitis”. She is leading one National Key R&D Project of the MOST, two major NSFC Projects, and one CAMS Innovation Fund for Medical Science. She has published more than 200 peer-reviewed papers in Blood, Ann Rheum Dis, Natl Sci Rev, Microbiome and other journals. Dr. Wang is currently the Director of Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Co-Director of one Innovation Research Unit of CAMS, and Co-Director of the Joint Laboratory of Skin Phenome. She serves as the President of Shanghai Society of Anthropology, and Associate Board Director and Executive Committee Member of the International Network of Scleroderma Clinical Care and Research (InSCAR).