鄭琰

發布時間：2021-06-27瀏覽次數：3680

教師基本信息

姓名：鄭琰YanZheng

職稱：研究員Principal investigator

電子郵箱：yan_zheng@fudan.edu.cn

辦公地點：C601


研究方向

從事肥胖和營養的分子流行病學研究，應用高通量多組學（尤其是代謝組和人體微生物組）技術發現疾病和飲食的生物標誌物，探索飲食與基因交互作用等。

Dr. Zheng’s research primarily focuses on elucidating the role of diet and lifestyle factors contributing to the development of cardiometabolic diseases, such as obesity, diabetes, and cardiovascular disease. In particular, Dr. Zheng is interested in utilizing multi-omics methodologies, especially metabolomics and metagenomics, to probe the intricate mechanisms underlying the exposure-disease association. Her research area also includes gene-diet interaction and Mendelian randomization studies in the cardiometabolic disease.


個人簡介：

2005年獲首都醫科大學臨床醫學學士學位，2008年獲複旦大學上海醫學院內科學碩士學位。2008-2010年就讀於美國Emory大學並獲公共衛生碩士學位，2010-2013年就讀於美國德州大學公共衛生學院並獲流行病學博士學位。2014-2017在美國哈佛大學陳曾熙公共衛生學院從事博士後研究。2017年加入複旦大學生命科學學院，任青年研究員、博士生導師、遺傳工程國家重點實驗室PI、複旦大學附屬中山醫院雙聘教授，2021年12月聘為複旦大學研究員。

Dr. Zheng received a bachelor’s degree in clinical medicine from Capital Medical University in 2005 and graduated from Shanghai Medical School Fudan University in 2008 with a master's degree in clinical cardiology. Then Dr. Zheng received her MPH from Emory University in 2010 and PhD in Epidemiology from University of Texas School of Public Health in 2013. She had her postdoctoral training in Department of Nutrition, Harvard T.H. Chan School of Public Health, from 2014 to 2017. In July 2017, Dr. Zheng joined the School of Life Sciences Fudan University as anassociate professor. In December 2021, she was tenured as a professor.

擔任中國營養學會營養流行病分會/基礎營養學分會委員、Molecular Genetics and Genomics雜誌副主編等多個學術兼職職務。以重要作者身份在JAMA、Nature Reviews Endocrinology、BMJ、Diabetes Care、Natl Sci Rev等雜誌上發表文章，多篇入選ESI高被引論文並受到國內外媒體報道。

Dr. Zheng has served as a member of the Nutritional Epidemiology and Basic Nutrition Branches of the Chinese Nutrition Society, an associate editor of Molecular Genetics and Genomics journal and other academic activities. Her scholar contributions, particularly as a significant author, are evident in a plethora of articles published in top-tier journals such as JAMA, Nature Reviews Endocrinology, BMJ, Diabetes Care, and Natl Sci Rev.


授課情況：

1. 本科生全英文課程bioethics；

2. 研究生必修課《科研倫理與規範》


  1. Bioethics (an English course for undergraduate students majoring in Biology);

  2. Research Ethics and Norms (a compulsory course for graduate students majoring in Biology)


招生專業：

遺傳學、生物信息學、生物學、生物醫藥

Genetics, Bioinformatics, Biology, Biomedicine


科研項目：

  1. 國家科學技術部國家重點研發項目（2021-2026 年）課題主持

  2. 複旦大學義烏基地項目（2021-2023年）主持

  3. 國家科學技術部國家重點專項（2019-2023 年）參與

  4. 上海市東方學者計劃（人才項目）（2019-2012年）

  5. 國家自然科學基金麵上基金項目（2019-2023年）主持

  6. 國家自然科學基金應急基金項目（2018年）主持

  7. 上海市浦江人才計劃（人才項目）（2018-2019年）


  1. National Key R&D Program of China (2021-2026), co-PI

  2. Basic Project by Yiwu Research Institute of Fudan University (2021-2023), PI

  3. National Key R&D Program of China (2019-2023), Participate

  4. Shanghai Oriental Scholar (2019-2012)

  5. National Natural Science Foundation of China (2019-2023), PI

  6. National Natural Science Foundation of China (2018), PI

  7. Shanghai Pujiang Talents(2018-2019）


獲獎情況：

  1. 入選2023年度“全球前2%頂尖科學家榜單”

  2. 複星獎教金一等獎（2022年）

  3. 2022年度“中國高被引學者”


  1. Selectedin the 2023 "Top 2% of Global Scientists List"

  2. First prize of Fosun Education Gold Award (2022)

  3. Highly Cited Chinese Researchers (2022)


代表性論文和論著：

  1. Senying Lai, Yan Yan, Yanni Pu,Shuchun Lin, Jian-Ge Qiu,Bing-Hua Jiang, Marisa Isabell Keller, Mingyu Wang, Peer Bork*, Wei-Hua Chen*, Yan Zheng*. Xing-Ming Zhao*, Enterotypes of the human gut mycobiome. Microbiome 2023 Aug 11;11(1):179

  2. Yuxiang Dai, Zhonghan Sun, Yan Zheng*, Junbo Ge*. Recent advances in the gut microbiome and microbial metabolites alterations of coronary artery disease. Science Bulletin 2023 Mar 30;68(6):549-552.

  3. Zhonghan Sun#, Xiong-Fei Pan#, Xiao Li, Limiao Jiang, Ping Hu, Yi Wang, Yi Ye, Ping Wu, Bin Zhao, Jianguo Xu, Mengmeng Kong, Yanni Pu, Manying Zhao, Jianying Hu, Jinfeng Wang, Guo-Chong Chen, Changzheng Yuan, Yongfu Yu, Xiang Gao, Fangqing Zhao, An Pan*, Yan Zheng*. The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case-control Study of Gestational Diabetes Mellitus. Advanced Science 2023 Jan 22; e2205289.

  4. Chenhao Lin#, Zhonghan Sun#, Zhendong Mei#, Hailuan Zeng, Maying Zhao, Jianying Hu, Mingfeng Xia, Tao Huang, Chaolong Wang, Xin Gao, Yan Zheng*. The causal associations of circulating amino acids with blood pressure: A Mendelian randomization study. BMC Medicine (2022) 20:414.

  5. Kang Yao, Yuxiang Dai, Juan Shen, Yi Wang, Huanjie Yang, Runda Wu, Qijun Liao, Hongyi Wu, Xiaodong Fang, Shalaimaiti Shali, Lili Xu, Meng Hao, Chenhao Lin, Zhonghan Sun, Yilian Liu, Mengxin Li, Zhen Wang, Qiang Gao, Shuning Zhang, Chenguang Li, Wei Gao, Lei Ge, Yunzeng Zou, Aijun Sun, Juying Qian, Li Jin, Shangyu Hong*, Yan Zheng*, Junbo Ge*. Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese. National Science Review 2022 May 31;9(8): nwac102.

  6. Zhonghan Sun#, Zhi-Gang Song#, Chenglin Liu#, Shishang Tan#, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding, Feng Qian, Yan Zheng*, Yan-Mei Chen*. Gut microbiome alterations and gut barrier dysfunction were associated with host immune homeostasis in COVID-19 patients. BMC Medicine 2022 Jan 20;20(1):24.

  7. Yan Zheng, Yanping Li, Ambika Satija, An Pan, Mercedes Sotos-Prieto, Eric Rimm, Walter C. Willett, and Frank B. Hu. Association of Changes in Red Meat Consumption with Total and Cause-Specific Mortality among U.S. Women and Men: Two Large Prospective Cohort Studies. The BMJ 2019 June 12; doi:10.1136/bmj. I2110.

  8. Drouin-Chartier JP*#, Zheng Y*, Li Y, Malik V, Pan A, Bhupathiraju SN, Tobias DK, Manson JE, Willett WC, Hu FB#. Changes in Consumption of Sugary Beverages and Artificially Sweetened Beverages and Subsequent Risk of Type 2 Diabetes: Results from Three Large Prospective U.S. Cohorts of Women and Men. Diabetes Care. 2019 Dec;42(12):2181-2189.

  9. Yan Zheng, Sylvia H Ley, Frank B Hu. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol2018 Feb;14(2):88-98.

  10. Yan Zheng, JoAnn E. Manson, Changzheng Yuan, Matthew H. Liang, Francine Grodstein, Meir J. Stampfer, Walter C. Willett, and Frank B. Hu. Associations of weight gain from early to middle adulthood with major health outcomes in later life. Journal of the American Medical Association (JAMA) 2017;318(3):255-269.


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