邴健

發布時間:2021-06-27瀏覽次數:5557

教師基本信息:

姓名:邴健Jian Bing

職稱:青年副研究員Vice Associate Professor

電子郵箱:bingj@fudan.edu.cn

辦公地點:複旦大學生命科學學院D509Room D509School of life Sciences, Fudan University

辦公電話:021-31246551


研究方向:

人體病原真菌念珠菌流行病學與防控,致病機理和耐藥進化機製,主要包括:

  1. 念珠菌形態發育和致病性調控網絡研究。

  2. 念珠菌耐藥機製與進化研究。

  3. 超級真菌流行病學與防控診治研究。

Epidemiology and prevention and control of human pathogenic Candida species, studying the molecular basis of drug resistance and morphological development of pathogenic Candida species

  1. Morphological development and pathogenesis regulation network of Candida genus.

  2. Mechanism and evolution of drug resistance of Candida genus.

  3. Epidemiology, prevention, and treatment of super fungi Candida auris.


個人簡介:

邴健,博士、青年副研究員。2011年畢業於北京化工大學,獲得學士學位。2016年畢業於中國科學院微生物研究所,獲得理學博士學位。2016-2019年任中國科學院微生物研究所助理研究員。2019年起任複旦大學生命科學學院青年副研究員。

近年來,在多重耐藥性“超級真菌”耳念珠菌感染機理及防治方麵取得了重要的進展。以第一作者在PLoS pathogensCurrent BiologyEmerging infectious diseasesEmerging Microbes & InfectionsAntimicrob Agents Chemother等國際著名雜誌上發表了一係列水平文章,Cell Host & Microbe等雜誌和Faculty of 1000 網站介紹和評論過這些文章。

Bachelor's degree (2007-2011), Beijing University of Chemical. Technology; Doctor's degree (2011-2016), Institute of Microbiology, Chinese Academy of Sciences; Assistant professor (2016-2019), Institute of Microbiology, Chinese Academy of Sciences; Vice Associate Professor (2019-present), School of life Sciences, Fudan University.

In recent years, significant progress has been made in the mechanism and prevention of multi drug resistant "super fungi" Candida auris infection. As first author, I have published a series of high-level articles in internationally renowned journals such as PLoS pathogens, Current Biology, Emerging infectious diseases, Emerging Microbes & Infections, and Antimicrobial Agents Chemistry. These articles have been introduced and commented by Cell Host & Microbe and the Faculty of 1000 website.


授課情況:

微生物分子遺傳與代謝

Microbial Molecular Genetics and Metabolism


科研項目:

1國家自然科學基金青年科學基金(2021-2023),主持Youth Fundation of the National Natural Science Foundation of China (2021-2023)host

2國家自然科學基金麵上項目(2022-2025),主持General Program and one Youth Fundation of the National Natural Science Foundation of China(2022-2025)host

3國家重點研發計劃病原學與防疫技術體係研究專項(2022-2025),參與National Key Research and Development Program of China (2022-2025)participant


代表性論文和論著:

  1. Bing J#, Guan Z#, Zheng T, Zhang Z, Fan S, Ennis CL, Nobile CJ, Huang G*, 2023. Clinical isolates of Candida auris with enhanced adherence and biofilm formation due to genomic amplification of ALS4. PLoS Pathog, 19(3): e1011239.

  2. Du H#, Bing J#, Xu X#, Zheng Q, Hu T, Hao Y, Li S, Nobile CJ, Zhan P, Huang G*, 2023. Candida vulturna Outbreak Caused by Cluster of Multidrug-Resistant Strains, China. Emerg Infect Dis, 29(7): 1425-1428.

  3. Fan S#, Zhan P#, Bing J#, Jiang N, Huang Y, Chen D, Hu T, Du H, Huang G*, 2021. A biological and genomic comparison of a drug-resistant and a drug-susceptible strain of Candida auris isolated from Beijing, China. Virulence, 12(1): 1388-1399.

  4. Tian S#, Bing J#, Chu Y#, Chen J, Cheng S, Wang Q, Zhang J, Ma X, Zhou B, Liu L, Huang G, Shang H*, 2021. Genomic epidemiology of Candida auris in a general hospital in Shenyang, China: a three-year surveillance study. Emerg Microbes Infect, 10(1): 1088-1096.

  5. Bing J#, Hu T#, Zheng Q, Munoz JF, Cuomo CA, Huang G*, 2020. Experimental evolution identifies adaptive aneuploidy as a mechanism of fluconazole resistance in Candida auris. Antimicrob Agents Chemother, 65(1): e01466-01420. (F1000推薦文章)

  6. Bing J#, You Z#, Zheng Q#, Tang J, Ran Y*, Huang G*, 2019. Biological and genomic analyses of a clinical isolate of Yarrowia galli from China, Current Genetics, 66(3): 549-559.

  7. Yue H#, Bing J#, Zheng Q, Zhang Y, Hu T, Du H, Wang H, Huang G*, 2018. Filamentation in Candida auris, an emerging fungal pathogen of humans: passage through the mammalian body induces a heritable phenotypic switch, Emerg Microbes Infect, 7(1): 0-188.

  8. Wang X#, Bing J#, Zhen Q#, Zhang F, Liu J, Yue H, Tao L, Du H, Wang Y, Wang H*, Huang G*, 2018. The first isolate of Candida auris in China: clinical and biological aspects, Emerg Microbes Infect, 7(1): 0-93.

  9. Bing J#, Han P, Liu W, Wang Q, Bai F*, 2014. Evidence for a Far East Asian origin of lager beer yeast, Current Biology, 24(10): R380-R381.


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