教師基本信息
姓名：鄧戀
職稱：青年研究員
電子郵箱：denglian@fudan.edu.cn
辦公地點：複旦大學江灣校區生命科學樓D615
鄧戀，女，青年研究員，博士生導師。2017年獲中國科學院大學計算生物學專業博士學位；同年入職中國科學院上海生命科學研究院（後更名為中國科學院上海營養與健康研究所），曆任助理研究員、副研究員；2021年9月進入複旦大學生命科學學院，任青年研究員。長期從事群體遺傳學和基因組學研究，在Nature,Molecular Biology and Evolution, Nature Communications，National Science Review，Nucleic Acids Research，Genome Biology，American Journal of Human Genetics等國際知名期刊發表多篇研究論文，擔任國家自然科學基金麵上項目和青年項目負責人，並作為課題骨幹參與兩項國家重點研發計劃課題；2019年入選上海市青年科技英才“揚帆計劃”；2020年獲法國賽諾菲安萬特-中科院上海生科院青年科技人才獎；2021年入選中國科學院青年創新促進會會員；現任中國遺傳學會青年委員會委員，上海人類學學會“分子人類學”專業委員會常務委員、上海市遺傳學會青年委員會委員。
研究方向
群體遺傳學/基因組學/計算生物學
1. 人群遺傳多樣性和適應性進化
2. 人類表型和疾病的遺傳基礎和演化曆程
代表性論文和論著
[1] Sihan Chen#, Die Tang#, Lian Deng*, and Shuhua Xu*. 2023. Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection. iScience.27(5):109560.
[2] Yang Gao#, Xiaofei Yang#, Hao Chen#, Xinjiang Tan#, Zhaoqing Yang#, Lian Deng#, Baonan Wang, Shuang Kong, Songyang Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Hao Sun, Xiaohan Xhao, Yingbing Shi, Ziyi Yang, Dongdong Wu, Shaoyuan Wu, Xingming Zhao, Binyin Shi, Li Jin, Zhibin Hu, Chinese Pangenome Consortium (CPC), Yan Lu*, Jiayou Chu*, Kai Ye*, and Shuhua Xu*. 2023. A pangenome reference of 36 Chinese populations. Nature.619:112-121.
[3]Lian Deng, Bo Xie, Yimin Wang, Xiaoxi Zhang, and Shuhua Xu*. 2022. A protocol for applying a population-specific reference genome assembly to population genetics and medical studies. STAR Protocols.3:101440
[4]Lian Deng#, Yuwen Pan#, Yinan Wang, Hao Chen, Kai Yuan, Sihan Chen, Dongsheng Lu, Siti Shuhada Mokhtar, Thuhairah Abdul Rahman, Boon-Peng Hoh, Shuhua Xu*. 2022. Genetic connections and convergent evolution of tropical indigenous peoples in Asia. Molecular Biology and Evolution.39(2):msab361
[5] Kai Yuan#, Xumin Ni#, Chang Liu#, Yuwen Pan#, Lian Deng#, Rui Zhang#, Yang Gao, Xuiling Ge, Jiaojiao Liu, Xixian Ma, Haiyi Lou, Taoyang Wu, Shuhua Xu*. 2021. Refining models of archaic–modern human admixture in Eurasia with ArchaicSeeker 2.0.Nature Communications.12:6232
[6]Lian Deng, Shuhua Xu*. 2021. ‘Chapter 3: Population Genomics of High-Altitude Adaptation’ in Naruya Saitou, Evolution of the Human Genome II: Modern Human Dispersal.Springer, Japan. 67-100
[7] Boon-Peng Hoh#, Xiaoxi Zhang#, Lian Deng#, Kai Yuan, Chee-Wei Yew, Woei-Yuh Saw, Mohammad Zahirul Hoque, Farhang Aghakhanian, Maude E Phipps, Yik-Ying Teo, Vijay Kumar Subbiah*, Shuhua Xu*. 2020. Shared signature of recent positive selection on the TSBP1–BTNL2–HLA-DRAgenes in five native populations from North Borneo. Genome Biology and Evolution. doi: 10.1093/gbe/evaa207.
[8]Lian Deng#, Haiyi Lou#, Xiaoxi Zhang#, Thiruvahindrapuram Bhooma, Dongsheng Lu, Christian R Marshall, Chang Liu, Bo Xie, Wanxing Xu, Lai-Ping Wong, Chee-Wei Yew, Aghakhanian Farhang, Rick Twee-Hee Ong, Mohammad Zahirul Hoque, Abdul Rahman Thuhairah, Bhak Jong, Maude E Phipps, Stephen W Scherer, Yik-Ying Teo, Subbiah Vijay Kumar*, Boon-Peng Hoh*, Shuhua Xu*. 2019. Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations. BMC Genomics.20:842.
[9] Ouzhuluobu#, Yaoxi He#, Haiyi Lou#, Chaoying Cui#, Lian Deng#, Yang Gao, Wangshan, Zheng, Yongbo Guo, Xiaoji Wang, Zhilin Ning, Jun Li, Bin Li, Caijuan Bai，Baimakangzhuo，Gonggalanzi, Dejiquzong, Bianba, Duojizhuoma, Shiming Liu, Tianyi Wu, Shuhua Xu*, Xuebin Qi*, Bing Su*. 2019. De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation. National Science Review.7(2):391-402.
[10]Lian Deng#, Chao Zhang#, Kai Yuan#, Yang Gao#, Yuwen Pan,Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu*. 2019. Prioritizing natural selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders. National Science Review.6(6):1201–1222.
[11] Chee-Wei Yew#, Dongsheng Lu#, Lian Deng#, Lai-Ping Wong#, Rick Twee-Hee Ong, Yan Lu, Xiaoji Wang, Yushimah Yunus, Farhang Aghakhanian, Siti Shuhada Mokhtar, Mohammad Zahirul Hoque, Christopher Lok-Yung Voo, Thuhairah Abdul Rahman, Jong Bhak, Maude E. Phipps, Shuhua Xu, Yik-Ying Teo, Subbiah Vijay Kumar*, Boon-Peng Hoh*. 2018. Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia. Human Genetics.137(2):161-173.
[12]Lian Deng and Shuhua Xu*. 2018. Adaptation of human skin color in various populations. Hereditas.155:1.
[13]Lian Deng, Andres Ruiz-Linares, Shuhua Xu* & Sijia Wang*. 2016. Ancestry variation and footprints of natural selection along the genome in Latin American populations. Scientific Reports.6:21766.
[14]Lian Deng, Boon-Peng Hoh, Dongsheng Lu, Woei-Yuh Saw, Rick Twee-Hee Ong, Anuradhani Kasturiratne, H. Janaka de Silva, Bin Alwi Zilfalil, Norihiro Kato, Ananda R. Wickremasinghe, Yik-Ying Teo & Shuhua Xu*. 2015. Dissecting the genetic structure and admixture of four geographical Malay populations. Scientific Reports.5:14375.
[15]Lian Deng, Boon Peng Hoh, Dongsheng Lu, Ruiqing Fu, Maude E. Phipps, Shilin Li, Ab Rajab Nur‑Shafawati, Wan Isa Hatin, Endom Ismail, Siti Shuhada Mokhtar, Li Jin, Bin Alwi Zilfalil, Christian R. Marshall, Stephen W. Scherer, Fahd Al‑Mulla, Shuhua Xu*. 2014. The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia. Human Genetics.133(9):1169-1185
[16] Wei Qian#, Lian Deng#, Dongsheng Lu, Shuhua Xu*. 2013. Genome-Wide Landscapes of Human Local Adaptation in Asia. PLoS One.8(1):e54224.