教師基本信息：
姓名：焦娜
職稱：青年研究員
電子郵箱：najiao@fudan.edu.cn
辦公地點：江灣校區生命科學學院
研究方向：
微生物與宿主互作；
微生物資源挖掘；
微生物組學分析方法及平台開發
個人簡介：
焦娜，青年研究員，博士生導師。2014年畢業於吉林大學獲得工學學士學位，2019年在同濟大學獲得生物學博士（生物信息學方向），2019-2021年在中山大學附屬第六醫院進行博士後研究。2021-2023年在浙江大學醫學院附屬兒童醫院國家兒童健康與疾病臨床醫學研究中心任特聘研究員，2024年1月入職複旦大學生科院微生物學與免疫學係，任青年研究員。研究聚焦於微生物與宿主互作、微生物資源挖掘和微生物組學分析方法及平台開發。近年來圍繞微生物與慢病防治、微生物-宿主互作在Nature Microbiology、Nature Communications、Cell Reports Medicine、Gut和Gut Microbes等期刊上發表了多篇研究論文。入選博士後創新人才支持計劃和獲得國家自然科學基金青年科學基金項目資助。
招生專業：微生物學、生物信息學
科研項目：
• 國家自然科學基金青年科學基金項目，82000536，腸道菌群介導的膽汁酸代謝通過腸肝軸誘導NAFLD的病理機製探究，2021.01-2023.12，主持
• 高校基本科研業務費青年教師培育項目，20ykpy07，FUT基因突變型炎症性腸病中腸道菌群的改變及其介導的病理機製研究，2020.01-2021.01，主持
• 博士後科學基金麵上資助，2019M663252，腸道菌群膽堿代謝在NAFLD發病機製中的作用研究，2020.01-2021.08，主持
• 博士後創新人才支持計劃，BX20190393，非酒精性脂肪肝病發病機製中膽酸代謝菌種確定及個性化幹預研究，2019.09-2021.08，主持
代表性論文和論著：
1. Xinyue Zhu#, Pingping Xu#, Ruixin Zhu*, Wenxing Gao, Wenjing Yin, Ping Lan, Lixin Zhu*, Na Jiao*, Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis, Communications Biology, 2024, 10.1038/s42003-023-05714-0
2. Wenxing Gao#, Xiang Gao#, Lixin Zhu*, Sheng Gao, Ruicong Sun, Zhongsheng Feng, Dingfeng Wu, Zhanju Liu*, Ruixin Zhu*, Na Jiao*, Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer. Gut Microbes, 2023, 15(2):2245562.
3. Xiang Gao#, Ruicong Sun#,Na Jiao#, Xiao Liang, Gengfeng Li, Han Gao, Xiaohan Wu, Muqing Yang, Chunqiu Chen, Liang Chen, Wei Wu, Zhong Li, Yingzi Cong, Ruixin Zhu*, Tiannan Guo*, Zhanju Liu*, Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease. Cell Reports Medicine. 2023;4, 101050.
4. Ningning Liu#,Na Jiao#, Jing-Cong Tan#, Ziliang Wang#, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Io Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nature Microbiology, 2022; 7(2):238-250. (ESI)
5. Dingfeng Wu#, Lei Liu#,Na Jiao#, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu*, Rohit Loomba*, and Ruixin Zhu*. Targeting Keystone Species Helps Restore the Dysbiosis of Butyrate‐Producing Bacteria in Nonalcoholic Fatty Liver Disease. iMeta. 2022 1(4): e61
6. Yuqi Wu#,Na Jiao#, Ruixin Zhu*, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Ping Lan, Chuan Tian*, Ning-Ning Liu*, Lixin Zhu*. Identification of microbial markers across populations in early detection of colorectal cancer. Nature Communications, 2021; 12(1):3063. (ESI)
7. Na Jiao, Susan S Baker*, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J Buck, Robert D Baker, Robert J Genco, Ruixin Zhu*, Lixin Zhu*. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut. 2018; 67(10):1881-1891 (ESI)
8. Na Jiao#, Susan S. Baker, Colleen A. Nugent, Maria Tsompana, Liting Cai, Yong Wang, Michael J. Buck, Robert J. Genco, Robert D. Baker, Ruixin Zhu*, Lixin Zhu*. Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiological Genomics. 2018; 50(4):244-254. (APSselectaward)
Research Focus:
Interactions Between Microbiota and Hosts;
Exploration and Mining of Microbiome;
Advancement and Development of Metagenomic Analysis Techniques and Platforms.
Personal Introduction:
Na Jiao, PI of Microbiome Systems Biology research group, doctoral supervisor. She graduated from Jilin University in 2014 with a Bachelor of Engineering degree and earned a Ph.D. in Biology (Bioinformatics) from Tongji University in 2019. She conducted postdoctoral research at the Sixth Affiliated Hospital of Sun Yat-sen University from 2019 to 2021. From 2021 to 2023, she served as a distinguished researcher at the National Clinical Research Center for Child Health and Diseases, Children's Hospital, Zhejiang University School of Medicine. In January 2024, she joined the Department of Microbiology and Immunology at Fudan University as a young researcher. Her research focuses on interactions between microbiota and hosts, exploration and mining of microbiome, and advancement and development of metagenomic analysis techniques and platforms. In recent years, she has published numerous research papers in prestigious journals such as Nature Microbiology,Nature Communications,Cell Reports Medicine,Gut, and Gut Microbes, primarily revolving around the prevention and treatment of chronic diseases through microbiome and host-microbiota interactions. She has been recognized in the Postdoctoral Innovative Talent Support Program and has received funding from the National Natural Science Foundation of China's Young Scientists Fund.
Admission Specialties: Microbiology, Bioinformatics.
Research Project:
• National Natural Science Foundation of China, Young Scientists Fund, 82000536, Mechanism for the gut microbiota-mediated bile acid metabolism promoting NAFLD pathogenesis via gut-liver axis, 2021-01 to 2023-12, PI
• Higher Education Institutions Fundamental Research Project, Young Teachers Training Programs, 20ykpy07, Altered gut microbiome and mechanism in FUT2 loss-of-function mutants in inflammatory bowel disease, 2020-01to 2021-01, PI
• China Postdoctoral Science Foundation, General Program, 2019M663252, Role of the choline metabolizing microbiota in the pathogenesis of non-alcoholic fatty liver disease, 2020-01to 2021-08，PI
• China Postdoctoral Science Foundation, Postdoctoral Innovative Talent Support Program, BX20190393, Identification of bile acid metabolizing bacteria and individualized intervention in the pathogenesis of nonalcoholic fatty liver disease, 2019-09 to 2021-08, PI
Representative Publications and Works:
• Xinyue Zhu#, Pingping Xu#, Ruixin Zhu*, Wenxing Gao, Wenjing Yin, Ping Lan, Lixin Zhu*, Na Jiao*, Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis, Communications Biology, 2024, 10.1038/s42003-023-05714-0
• Wenxing Gao#, Xiang Gao#, Lixin Zhu*, Sheng Gao, Ruicong Sun, Zhongsheng Feng, Dingfeng Wu, Zhanju Liu*, Ruixin Zhu*, Na Jiao*, Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer. Gut Microbes, 2023, 15(2):2245562.
• Xiang Gao#, Ruicong Sun#,Na Jiao#, Xiao Liang, Gengfeng Li, Han Gao, Xiaohan Wu, Muqing Yang, Chunqiu Chen, Liang Chen, Wei Wu, Zhong Li, Yingzi Cong, Ruixin Zhu*, Tiannan Guo*, Zhanju Liu*, Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease. Cell Reports Medicine. 2023;4, 101050.
• Ningning Liu#,Na Jiao#, Jing-Cong Tan#, Ziliang Wang#, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Io Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nature Microbiology, 2022; 7(2):238-250. (ESI)
• Dingfeng Wu#, Lei Liu#,Na Jiao#, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu*, Rohit Loomba*, and Ruixin Zhu*. Targeting Keystone Species Helps Restore the Dysbiosis of Butyrate‐Producing Bacteria in Nonalcoholic Fatty Liver Disease. iMeta. 2022 1(4): e61
• Yuqi Wu#,Na Jiao#, Ruixin Zhu*, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Ping Lan, Chuan Tian*, Ning-Ning Liu*, Lixin Zhu*. Identification of microbial markers across populations in early detection of colorectal cancer. Nature Communications, 2021; 12(1):3063. (ESI)
• Na Jiao, Susan S Baker*, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J Buck, Robert D Baker, Robert J Genco, Ruixin Zhu*, Lixin Zhu*. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut. 2018; 67(10):1881-1891 (ESI)
• Na Jiao#, Susan S. Baker, Colleen A. Nugent, Maria Tsompana, Liting Cai, Yong Wang, Michael J. Buck, Robert J. Genco, Robert D. Baker, Ruixin Zhu*, Lixin Zhu*. Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiological Genomics. 2018; 50(4):244-254. (APSselectaward)